The Fur Trade Highway is a historic route that spans from the east bank of the Missouri River in present-day northeastern Nebraska, to the old trading posts near the Mississippi River in the western United States. Established in the early 19th century, the Fur Trade Highway played a significant role in the development of the United States as it facilitated trade between the East Coast and the Great Plains region. As part of Nebraska's Trails and Byways, this route provides a unique opportunity for travelers to follow in the footsteps of early explorers and traders who ventured into the vast and untamed American West.

One of the key landmarks along the Fur Trade Highway is the confluence of the Missouri and Big Sioux rivers near present-day Omaha-Council Bluffs metropolitan area. Here, the Lewis and Clark expedition camped in 1804, and the Arikara and Omaha tribes frequently met with early traders to barter for goods. The famous Cabanne's Trading Post, established in 1822, is another crucial stop along the highway. Located near present-day Fort Calhoun on the north bank of the Missouri River, this trading post served as a hub for the storage and exchange of goods such as beaver pelts, buffalo hides, and trade goods.

Travelers can explore historic sites along the way, such as Fontenelle's Post near present-day Bellevue, which was established in 1812 by Logan Fontenelle, a prominent fur trader. This post was instrumental in the development of the upper Missouri River fur trade, and it offers a glimpse into the complexities of relationships between European-American traders and Native American tribes during this period. Furthermore, the DeSoto Bend National Wildlife Refuge near present-day Missouri Valley serves as a reminder of the region's rich natural resources, including waterfowl and big game, which played a vital role in the sustenance and livelihood of early traders and Native American tribes.

Present-day travelers can drive along the historic Fur Trade Highway route by taking the Missouri River Scenic Byway, which traverses the state's eastern edge. Along the way, historic markers and interpretive signs provide insights into the history of the region. By taking this scenic route, travelers can explore the contours of the Missouri River valley, examine the once-thriving trading posts and villages, and get a firsthand sense of the vast open spaces and significant historical sites that dot the Nebraska landscape.

During their journey, travelers will encounter a diverse array of cultural and historical sites. The Lewis and Clark National Historic Trail Interpretive Center near present-day Omaha is a must-visit attraction that highlights the essential role that this area played in the epochal Lewis and Clark expedition. Similarly, the Sarpy County Historical Society Museum, which features exhibits on the region's pioneer era and early fur traders, provides in-depth context on the historical figures who traversed the Fur Trade Highway.

Considered a forerunner to modern trading systems, the Fur Trade Highway united ancient cultural connections with emergent international trade routes. While it dramatically affected Native American tribes and impacted the European-American population of the region, it also fostered cross-cultural understanding and laid the groundwork for industrial growth throughout the state.

Moreover, travelers visiting Nebraska's Fur Trade Highway today can visualize remnants of historic transportation networks, appreciate architectural styles, and be deeply impressed by the pioneering spirit that exemplified the bold endeavors undertaken along this trail.

Recognizing the remarkable intersection of historical and geographical paths that converged to form the Fur Trade Highway emphasizes Nebraska's function as a node between the American East Coast and Western territories during an era of remarkable change.