Located in the eastern part of the state, the Lewis And Clark Scenic Byway spans approximately 82 miles of scenic landscape, tracing the journey of the historic Lewis and Clark Expedition that occurred in 1804. This route weaves through the Missouri River Valley, near the town of Brownville in southeastern Nebraska, and onward to the cities of Plattsmouth and Omaha. Travelers who venture along this route will have the unique opportunity to experience the very same landscape, complete with stunning views of the Missouri River.

Historians are especially drawn to this byway, as many sections of the original Lewis and Clark trail still exist in relatively pristine form. The expedition's campsites and notable landmarks can be found throughout the journey, including the Stevens Creek Crossing, which marks a pivotal spot where the expedition encountered significant tribulations during their travels. One easily accessible site along the byway is the Chimney Rock State Historic Site in Bayard, located near the small town of Scott's Bluff (a geological rock formation considered a monumental milestone during their travels) – though Scott's Bluff does not lie upon the route.

Near the city of Plattsmouth, travelers can visit the Schilling Wildlife Management Area, a protected preserve of over 2,400 acres, used to mimic the habitat experienced by Lewis and Clark. To complete the experience, a stunning display of the landscape awaits those traversing the byway near the town of Brownville. Lined with vast stretches of cottonwood forests, and a sharp embankment along the massive Missouri River, which Lewis and Clark navigated using makeshift rafts to transport supplies.

Travelers benefit from meandering across various museums that have established themselves throughout the Lewis And Clark Scenic Byway to deliver specific displays centered around one of America's quintessential famous expeditionary groups. Nebraska, hosting miles of that journey, proudly supports a small but famous cluster of museums inside the town of Brownville that offers deep inside insight and keepsakes associated with the storied travels of these unique legends. This location houses a plethora of interesting details encompassing historical happenings which visitors may value when referencing this monumental byway.

The region, influenced by significant past events connected to the byway, showcases many similar heritage trails and walkways along its perimeter connected with other notable milestones concerning past expeditions passing through. Therefore, an assortment of travelers of this area stands as potential audience which will easily gain many of the inimitable local impressions gathered after experiencing historic landmarks.